Dicarbonyl Stress and Atherosclerosis: Is It All RAGE?
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چکیده
منابع مشابه
Dicarbonyl Stress and Atherosclerosis: Is It All RAGE?
Atherosclerotic vascular disease is a major cause of cardiovascular (CV) morbidity and mortality and a significant driver of health care costs in patients with diabetes. Systemic abnormalities, including dyslipidemia, insulin resistance, hyperinsulinemia, hyperglycemia, oxidative stress, accentuated renin-angiotensin system, and tissue inflammation, have been proposed to play a role in mediatin...
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A critical event in the development of atherosclerosis is the recruitment of macrophages to the underlying epithelial layer of blood vessel walls and the uncontrolled uptake of oxi-dized/modified cholesterol. Continued accumulation of oxi-dized/modified cholesterol by macrophages and an associated inflammatory response leads to foam cell formation and the initiation of atherosclerosis. 1 Revers...
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Macrovascular calcification increasingly afflicts our aging and dysmetabolic population.1 Once considered only a passive process of dead and dying cells, data from multiple laboratories worldwide have converged to reveal that vascular calcification is in great part an actively regulated form of matrix mineral metabolism.2 A uniquely horrendous situation arises in end-stage renal disease.3 Antec...
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Diabetes is characterized by accelerated atherosclerosis with widely distributed vascular lesions. An important mechanism by which hyperglycaemia contributes to vascular injury is through the extensive intracellular and extracellular formation of AGEs (advanced glycation end products). AGEs represent a heterogeneous group of proteins, lipids and nucleic acids, irreversibly cross-linked with red...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2014
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db14-0953